DailyDirt: This Is Your Brain On Caffeine. Any Questions?

from the urls-we-dig-up dept

Making the perfect cup of coffee is an experiment that's been studied for decades -- if not for hundreds of years since coffee was first brewed in the 1300s. It's not an exact science yet, but studies on coffee drinking seem to point to it being mostly beneficial. Here are just a few interesting links for coffee lovers out there. If you'd like to read more awesome and interesting stuff, check out this unrelated (but not entirely random!) Techdirt post via StumbleUpon.
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Filed Under: caffeine, coffee, decaf, decaffeinated coffee, drinks, drugs, food, health, medicine, pregnant

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  1. identicon
    Anonymous Coward, 31 Aug 2013 @ 7:30am

    Re: Re: caffeine factoid...

    7.2 Toxicity

    7.2.1 Human data Adults

    Lethal doses are estimated at 0.5 to
    1.3 grams per day by mouth; 0.05 to 5 grams
    per day by the nasal route, 0.02 grams of
    cocaine by the parenteral route (Baschard &
    Richard, 1984; Haddad & Winchester, 1990;
    Burnat & Le Brumant-Payen, 1992).
    Cocaine addicts can tolerate doses up to 5
    grams per day.
    Toxic effects can be manifest with plasma
    concentrations equal to or above 0.50 mg per
    litre; deaths have been reported with
    concentrations of 1 mg per litre (Clarke,
    1986). Children

    No data.

    7.2.2 Relevant animal data

    The LD50 for the rabbit is 15 mg per kilogram
    by the intravenous route, and 50 mg per kilogram by
    the nasal route; the intravenous LD50 for the rat is
    17.5 mg per kilogram (Budavari, 1989).

    7.2.3 Relevant in vitro data

    Experiments on animal heart tissue show a
    direct, reversible, depressant effect of cocaine on
    ventricular myocardium (Chokshi et al., 1989).
    Experiments on rats prove that alcohol potentiates the
    toxic effects of cocaine (Nahas et al., 1992).

    INCHEM: Cocaine - 7.2 Toxicity

    Some doctors estimate that 1.2 grams of cocaine, when used orally, and 750-800 milligrams, when used intravenously or by inhaling, is fatal. It is unknown how much cocaine is fatal when sniffed. (Source: Cocaine Vraagbaak, Federatie van Instellingen voor Alcohol en Drugs, 1986). A user sniffs 0.1-0.2 grams of cocaine, i.e., 2-4 lines a night.

    The average lethal dose of intravenous use of cocaine is about 500 milligrams. That doesn't mean, however that a smaller dose is safe. An estimated lethal dose when sniffing cocaine is unknown. These doses are estimates.


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